Doping genetico
Bibliografia
Baoutina A, Alexander IE, Rasko JE, Emslie KR. Potential use of gene transfer in athletic performance enhancement. Mol Ther 2007 Oct; 15(10): 1751-66.
Musarò A, McCullagh K, Paul A et al. Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle. Nat Genet 2001; 27(2): 195-200.
Lee S, Barton ER, Sweeney HL, Farrar RP. Viral expression of insulin-like growth factor-I enhances muscle hypertrophy in resistance-trained rats. J Appl Physiol 2004; 96(3): 1097-104.
Bogdanovich S, Krag TO, Barton ER, Morris LD, Whittemore LA, Ahima RS, Khurana TS. Functional improvement of dystrophic muscle by myostatin blockade. Nature 2002 28; 420(6914): 418-21.
Joulia-Ekaza D, Cabello G. The myostatin gene: physiology and pharmacological relevance. Curr Opin Pharmacol 2007; 7(3): 310-5.
Schuelke M, Wagner KR, Stolz LE, Hübner C, Riebel T, Kömen W, Braun T, Tobin JF, Lee SJ. Myostatin mutation associated with gross muscle hypertrophy in a child. N Engl J Med 2004; 350(26): 2682-8.
McPherron AC, Lawler AM, Lee SJ. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 1997; 387(6628): 83-90.
Birkeland KI, Stray-Gundersen J, Hemmersbach P, Hallen J, Haug E, Bahr R. Effect of rhEPO administration on serum levels of sTfR and cycling performance. Med Sci Sports Exerc 2000; 32(7): 1238-43.
Wells DJ. Gene doping: the hype and the reality. Br J Pharmacol 2008 Jun; 154(3): 623-31.
Perry JK, Emerald BS, Mertani HC, Lobie PE. The oncogenic potential of growth hormone. Growth Horm IGF Res 2006; 16(5-6): 277-89.
Baoutina A, Alexander IE, Rasko JE, Emslie KR. Developing strategies for detection of gene doping. J Gene Med 2008; 10(1): 3-20.
Guescini M, Fatone C, Stocchi L et al. Nutr Metab Cardiovasc Dis. Fine needle aspiration coupled with real-time PCR: a painless methodology to study adaptive functional changes in skeletal muscle. 2007; 17(5): 383-93.
Liew CC, Ma J, Tang HC, Zheng R, Dempsey A. The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool. J Lab Clin Med 2006; 147(3): 126-32.
Schulze JJ, Lundmark J, Garle M, Skilving I, Ekström L, Rane A. Doping test results dependent on genotype of uridine diphospho-glucuronosyl transferase 2B17, the major enzyme for testosterone glucuronidation.J Clin Endocrinol Metab 2008; 93(7): 2500-6.
de la Chapelle A, Träskelin AL, Juvonen E. Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis. Proc Natl Acad Sci USA 1993 15; 90(10): 4495-9.
Yang N, MacArthur DG, Gulbin JP et al. ACTN3 genotype is associated with human elite athletic performance. Am J Hum Genet 2003 Sep; 73(3): 627-31.